E. González, G. Sottilotta
Abstract
Thrombopathies are qualitative disorders of platelet function in which the platelet count is normal, but the ability to aggregate, adhere, or secrete granule contents is impaired. These conditions affect primary hemostasis, leading to prolonged bleeding even in the absence of thrombocytopenia.
Qualitative platelet disorders directly compromise the initiation and propagation of a stable hemostatic plug. Without proper platelet adhesion, activation, andaggregation, the initial sealing of the injured vessel is deficient. Furthermore, the critical role of activated platelets in providing a procoagulant surface for the assembly of coagulation factor complexes means that even with normal plasma coagulation factors, the overall efficiency of thrombin generation and subsequent fibrin clot formation is severely impaired.
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