The cost associated with a clinical condition can be categorized into three main categories: direct, indirect, and intangible. Direct costs are items that are more closely related to the disease and its treatment (e.g. drug treatment, hospitalizations, surgery, physiotherapy), indirect costs that are related to productivity varation due to the disease and its management, and intangible costs that refer to the consequences of a disease and of a medical treatment on individuals' quality of life.

Haemophilia is a condition with significant burdens and costs associated with all these three categories; however, the focus has always been on the direct costs associated with the drug treatment.

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